19 In the 1920s, German doctor Justinus Kerner discovered a toxin that caused food poisoning by spoiled sausages. The paralytic disease caused by Kerner's "sausage poison" won the title of "botulism" (from Latin "botulus"). Kerner speculated that small doses of botulinum toxin may be used to treat neurological disorders and hyperhidrosis.
1895, Belgian bacteriologist Emile Pierre van Ermengem discovered that botulinum can produce botulinum toxin.
In the 1920s, botulinum toxin A was extracted. Dr Herman Sommer of the University of California, San Francisco, USA, was the first to extract botulinum toxin A in stable acid precipitation form from botulinum.
In the 1940s, during World War II, American scientists began to explore the potential use of botulinum toxin, trying to turn it into a weapon of war. The United States produces botulinum toxin capsules for prostitutes in China and throws them into the food of senior Japanese generals. However, the plan of the US military did not succeed, because they found that botulinum toxin was useless as a weapon of war.
1949, in London, England, researcher Dr. Arnold Burgen and his colleagues found that botulinum toxin can block the connection between nerve and muscle.
In 1960s, alan scott, an ophthalmologist in San Francisco, injected monkeys with botulinum toxin to see if they could relax the muscles that caused strabismus.
1978: Dr. Scott obtained the approval of the US Food and Drug Administration (FDA) and conducted a wide range of dynamic tests on the use of botulinum toxin to treat human strabismus. He named the drug Oculinum and established Oculinum company to produce and sell the drug.
1989: Oculinum is approved by FDA for the treatment of strabismus and ptosis.
200 years later, 6.4 out of 10 people planted grass for others and gave them face-lifting needles.
From April 65438 to May 2002, botulinum toxin was approved by FDA as a medical cosmetic material, which was mainly used to remove wrinkles by injection and temporarily improve moderate and severe brow wrinkles. This major event undoubtedly makes botulinum toxin a "face savior" for beauty lovers. Today: Botox is still an ideal choice for many beauty seekers to face-lift and wrinkle-remove.
According to the American Society of Aesthetic Plastic Surgery (ASAPS), the output of face-lifting needles has increased by 67% since 2002. On average, 6.4 out of every 10 users said that the face-lifting needle was worth a try. The face-lifting needle we often talk about is actually "botulinum toxin". It was first discovered in spoiled sausages, and then applied to face wrinkle removal and beauty, becoming a "Hollywood star" in the medical and aesthetic circles and a "face savior" for beauty lovers. Botox has undergone a transformation for about 200 years.