Early diagnosis and treatment of scrotal cancer is very important. Strive for early surgical resection. The primary focus needs to be locally enlarged and removed, and the scope should exceed the scrotal wall and be more than 2cm away from the tumor edge. Unless the lesion has invaded the scrotal contents, it should be preserved as much as possible. Local recurrence after operation is often due to insufficient resection, but it may also be new rather than recurrence.

Mohs chemical surgery can also be used to remove lesions with too large and too wide a range, that is, to continuously observe the resected cancer tissue under a microscope until the tumor is completely resected. For those who are difficult to cover the scrotal contents because of the wide resection range, skin flap transfer and scrotal plasty can be used, and those whose scrotal contents have been affected should be removed together.

Because most of the patients are elderly, preventive inguinal lymph node dissection may not improve the survival rate, but it may easily lead to complications such as lymphatic reflux disorder of lower limbs, elephantiasis and poor wound healing. Therefore, ilioinguinal lymph node dissection can only be done if the enlarged lymph node biopsy proves metastasis. The operation can be performed 2 ~ 6 weeks after resection of the primary focus. After operation, deep X-rays can be added to radiotherapy or chemotherapy if necessary, but they are often insensitive. Patients with visceral or distant metastasis in the late stage of scrotal cancer can also use radiotherapy and chemotherapy as palliative adjuvant therapy, such as 60Co irradiation or cisplatin, bleomycin and methotrexate combined chemotherapy. These treatments can also be used to prevent recurrence after local resection.