Neurofibromatosis is a neuroectodermal abnormality caused by dominant inheritance. The incidence of children's soft fibroma is mainly a hemispherical or pedicled tumor of several millimeters to several centimeters on the trunk and proximal limbs. It is soft, pink or brown in color, and develops slowly with age. Lesions of elephantiasis-like multiple neurofibroma are often distributed along the nerve trunk, which are intradermal and subcutaneous soft nodules and plaques. About 10% patients developed malignant transformation, especially rapid growth and great damage, and developed into neurofibrosarcoma. Brown spots, common on the trunk, especially on the waist and back, are brown spots several centimeters in size, oval in shape and with clear boundaries. A few patients have papilloma and giant tongue in their mouth. Nearly half of them suffer from mental retardation, intracranial tumors and epilepsy. Adult patients with rapid disease development and large skin lesions have poor prognosis due to malignant transformation.

Classification of diseases: plastic surgery, dermatology, otolaryngology,

Neurofibroma, also known as fibromatosis and rubber neuroma, is a hereditary systemic neuroectodermal disease, which belongs to autosomal dominant inheritance, but its penetrance varies, and about 25% ~ 50% of patients have a positive family history. The skin features of this disease are pigmented spots and multiple neurofibromas.