Patients with cleft lip and palate often need multidisciplinary doctors to treat them together because of congenital deformity of lip and maxilla and a series of secondary problems, and they need multiple treatments at different stages. The comprehensive treatment of cleft lip and palate is sequential, so it is also called sequential treatment of cleft lip and palate, and the steps are closely related. Early plastic surgery for infants solved the feeding difficulties of infants, promoted the remodeling of maxilla, and provided conditions for forming correct pronunciation habits. The participation of otolaryngologists has solved the problem of middle ear diseases that are easy to occur in patients with cleft lip and palate. Speech pathologists and phoneticians can carry out speech training before school to correct children's bad pronunciation. Are the defoliation and replacement periods wrong? The correction of deformity promoted the development of the patient's jaw; Alveolar bone transplantation in dentition replacement period makes the upper jaw connected into a whole and stabilizes the orthodontic effect, which is a characteristic malocclusion of cleft lip and palate in permanent teeth period. This creates conditions for correction and requires the participation of dentists and maxillofacial surgeons. Orthodontic treatment combined with restoration and surgical orthodontics can make patients achieve ideal? State and appearance; Psychologists can relieve patients' psychological problems caused by obstacles such as appearance and pronunciation in time. With the cooperation of various disciplines, patients with cleft lip and palate can get ideal correction after sequential treatment.