Severe patients should be hospitalized and given the maximum dose of antibiotics, keep airway unobstructed, nutritional support (including high-energy nutrition), blood products, skin care, physical therapy and necessary medical care. Strict hygiene measures can effectively reduce the damage to the ear canal, skin and gums. Debridement can even remove severely damaged gingival tissue to limit oral lesions. Seborrheic dermatitis of head can be treated with selenium-containing shampoo (twice a week). If the shampoo is ineffective, a small amount of corticosteroids can be used locally to control small lesions in a short time. Most patients with diabetes insipidus or other symptoms of pituitary hypofunction need hormone supplementation.
Local treatment (surgery and radiotherapy) after a complete evaluation, patients with single bone invasion and patients with multiple injuries in some cases can use local treatment. The patient's lesion is shallow, and surgical curettage can be performed in accessible and non-dangerous parts, but excessive orthopedic and functional damage should be avoided during the operation. Local radiotherapy (using high-voltage device) is often given to patients with skeletal deformity, visual impairment caused by exophthalmos, pathological fracture, spinal compression, spinal cord injury or severe pain, or generalized lymphadenopathy.
Children with low risk of chemotherapy > 2 years old who have single system diseases or bone damage in one or more parts are often given local treatment instead of systemic treatment. However, ineffective treatment or rising ESR may indicate the existence of serious systemic diseases. Low-risk patients >: 2 years old with multiple system diseases, but not invading blood system, liver, lung and spleen, can be given chemotherapy, which often has a lasting effect, but most of them are
Patients with poor prognosis should be matched with HLA at the time of diagnosis, and bone marrow transplantation, cyclosporine or experimental immunosuppression or other immunomodulatory treatments should be considered. For patients with systemic Langerhans cell histiocytosis, chronic disabilities that may be caused by disease and treatment should be monitored, such as cosmetic or functional orthopedic and skin injury and neurotoxicity, as well as mood swings.