Hyaluronic acid itself has a negative charge and exists in most soft connective tissues in animals. Its aqueous solution is a viscoelastic fluid, which fills the gap between cells and collagen fibers and covers some epidermal tissues. In animals, its main function is to protect and lubricate cells, regulate the movement of cells on this viscoelastic matrix, stabilize the collagen network structure and protect them from mechanical damage. Hyaluronic acid is a natural lubricating and damping polymer, so it is used as a lubricant on the surface of tendon, tendon sheath and stick-slip membrane. Hyaluronic acid is widely distributed in human connective tissue, and exists almost in pure state in bovine vitreous body and joint cavity. Hyaluronic acid (HA) existing in skin plays an important role in the metabolism of human epidermis. The destruction or imbalance of hyaluronic acid (HA) in human body will lead to diseases. The decrease and destruction of hyaluronic acid (HA) content in the skin will make the skin lose elasticity and wrinkle during dehydration, which will make the human epidermis aging. Therefore, HA is also called anti-aging factor. Hyaluronic acid (HA) is one of the main matrix components of human skin epidermis and dermis. Its physiological function is to make water enter the intercellular space, combine with protein to form protein gel, bond cells together, play a normal role in cell metabolism, keep cell moisture, protect cells from pathogenic bacteria, accelerate the recovery of skin tissue, improve the ability of wound healing and regeneration, reduce scars and enhance immunity. At the same time, hyaluronic acid is the main component of extracellular matrix of proliferating cells and migrating cells, especially in embryonic tissues. Hyaluronic acid, because of its own characteristics, can keep the isolation between cells, make cells easy to move, migrate and proliferate, and prevent cell differentiation. During development, the role of hyaluronic acid seems to be to prevent cells from differentiating prematurely before they proliferate or migrate in place. In medicine, hyaluronic acid (HA), as a non-steroidal anti-inflammatory drug, plays a unique role in treating burns, scalds, frostbite, artificial skin and so on.