400 kilometers. New york is located on the Atlantic coast in southeastern New York, USA. It is the largest city and port in the United States and the fourth largest city in the world. Located in the middle of new york, Syracuse, also known as Yancheng, is also called CENTRALNEWYORK. It is the fourth largest city and a medium-sized city in new york. The self-driving distance from new york to Syracuse is about 400 kilometers, which takes about 4 hours.