1, process difference: vacuum drying method is used for botulinum, and freeze drying method is used for gravity. It is relatively difficult for botulinum to produce antibodies, while botulinum toxin is easy to produce toxoid.

2. Composition difference: both excipients are protein, but the excipient of botulinum is human albumin, and the excipient of Hengli is pig gelatin. Heterogeneous protein is more likely to cause allergies.

3. Concentration difference: the molecular weights of the two are different. The molecular weight of botulinum is 900KDa (kilodalton), and the molecular weight of botulinum is relatively large, so the concentration of botulinum in unit dose is slightly higher.

4. Dispersion difference: The dispersion area after injection of Botox is 0.5 cm2, while that of standing is 1 cm2. The smaller the diffusion area, the less likely the botulinum toxin after injection will spread to other parts.