First, there is a high probability of graft-versus-host reaction in bone graft rejection of bone defect. The immune cells of the donor tissue attack the tissue antigen of the victim as a foreign body. With the growth and expansion of donor immune cells, the rejection of recipients is becoming more and more serious. (William Shakespeare, resident, immune cell, immune cell, immune cell, immune cell, immune cell, immune cell, immune cell, immune cell, immune cell) In severe cases, fatal reactions can be carried out at the same time. The main manifestations of graft-versus-host reaction are fever, rash, palpable hepatosplenomegaly, abnormal liver function, pancytopenia and severe diarrhea. This has a great impact on patients. Different bone marrow patients have different probability of this reaction. For example, the incidence of this reaction is 1% ~ 5% in twins, 36% in relatives and 50% ~ 70% in blood relationship. This reaction is very serious, but appropriate immunosuppression can weaken or avoid this reaction.
Second, bone transplantation with bone defect Bone transplantation with bone defect, namely hematopoietic stem cell transplantation, is a treatment method to rebuild the patient's normal hematopoietic and immune system and treat a series of diseases by intravenous injection of hematopoietic stem cells and hematopoietic cells. Hematopoietic stem cell transplantation basically replaced the term "bone marrow transplantation". Because hematopoietic stem cells not only come from bone marrow, but also from peripheral blood mobilized by hematopoietic factors. These hematopoietic stem cells can be used to rebuild hematopoietic and immune systems.
Third, the cause of bone defect Bone defect is a common disease in clinic, which means that the structural integrity of bones is destroyed. Next, let's take a look at what causes bone defects and what symptoms will appear in clinic. The biggest reasons for previous lives are as follows, among which congenital factors are the main reasons. This congenital malformation is mainly caused by insufficient nutrition acceptance of the fetus and mother, infection and various genetic factors. Traumatic factors are also one of the main factors causing this disease. Our common industrial injuries and burns will lead to the formation of bone defects. Another common factor is the parliamentarian factor. Then some of his diseases need surgery, so it will cause different degrees of bone defects after surgery.