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Scientists use genetic engineering technology to implant genes into skin cells, transforming human skin cells into stem cells that are almost comparable to embryonic stem cells.
First, the principle of genetic engineering technology is gene recombination, which can not produce new genes and make mistakes;

B, in the natural state, gene recombination occurs during meiosis, and B is correct;

C, gene recombination will not occur during mitosis, and C is wrong;

D. Colchicine can improve the mutation rate, but it can't provide the incidence of gene recombination. D is wrong.

Therefore, choose: B.