The research team took out 6,543.8+10,000 epithelial cells and 6,543.8+10,000 mesenchymal cells from the basic dental tissue of fetal rats, arranged them according to the actual density of teeth, transplanted them into collagen gel for culture, and cultivated organ seeds called "organ primordia". After that, 50 rats were injected subcutaneously. After 65.438+04 days, teeth including blood vessels and nerves were regenerated, and then transplanted until they could not be rejected. After 22 transplants, 17 teeth were successfully regenerated. Surface enamel, internal ivory, central blood vessels and nerves are all the same as normal teeth 100%. The research team also took out cells from the basic hair beard tissue of fetal rats, and transplanted them into the renal cortex of adult rats after the same culture, successfully regenerating hair and surrounding hair follicle cells.
This achievement is expected to replace denture inlay and promote the development of artificial organ regeneration technology. However, whether the regenerated teeth have enough hardness remains to be further studied in the future, and it will take time for them to be actually applied to the human body, and hair regeneration is expected to be realized within five years. In the future, further experiments will be conducted on the regeneration of organs such as liver and kidney.
If this regenerative technology is applied to humans, it is a very practical choice to abort the fetus. However, the researchers pointed out that this will be related to ethical issues and possible rejection of transplantation to others. Therefore, the feasible further research direction in the future is to find out the cells of tooth germ and hair tissue from the oral mucosa or scalp of patients who agree to receive regenerative medicine, and then carry out regenerative treatment on this basis. (