Long-term commitment to the pathogenesis, growth and development of congenital cleft lip and palate, and new technologies and methods of clinical treatment, the concept and surgical design of individualized cleft lip repair were put forward for the first time, which has been widely used in clinic and trained many doctors at home and abroad, including those from Japan Dental University. It is the first time in China to introduce computer technology into clinical operation design, effect evaluation and operation effect prediction of cleft lip, and to develop a computer-aided drawing, measurement and evaluation system for congenital unilateral cleft lip.

As the project leader, he has been supported by National Natural Science Foundation, Excellent Young Teachers' Teaching and Research Award Fund of Ministry of Education, Fok Ying-tung Youth Education Fund, American Plastic Surgery Education Foundation (PSEF), Start-up Fund for Returned Overseas Students of Ministry of Education, Ministry of Health and Sichuan Science and Technology Commission for four consecutive times. The etiology and pathogenesis of cleft lip and palate were studied by molecular pathology. Firstly, an animal model of congenital cleft palate in A-strain mice was established and applied in China, and it was expounded that the main causes of cleft palate were slow movement of the upper arm of palatal embryo process and insufficient development of palatal mesenchymal cells and matrix. It was found that the proliferation and metabolism of palatal embryo process were regulated by EGF, TGFα, TGFβVEGF and other factors networks. He also systematically studied the important functional substances Annexin and PLA2 in the signal transduction pathway of glucocorticoid, a teratogenic agent for cleft palate, and found that Annexin ⅰ and PLA2 are the * * * synergistic pathways for the proliferation of glucocorticoid and growth factors in high cavity cells, and their abnormal expression changes during embryogenesis are the basis for the formation of cleft palate.

At the same time, the method of preventing congenital cleft palate by VirB 12 was developed, and its mechanism was clarified. By establishing various animal models such as mice, rabbits and dogs, the growth and development of maxilla before and after cleft lip and palate surgery were gradually understood, and the difference of the influence of exposed bone area of hard palate on maxilla growth and development after cleft palate surgery was clarified. Autologous bone transplantation, bone-induced active biofilm, oral mucosa transplantation and tissue-engineered oral mucosa transplantation with interferon α secretion function were used to prevent secondary maxillary deformity after cleft lip and palate surgery.

Editor-in-Chief: Course of Cleft Lip and Palate Repair Surgery and Oral Clinical Experiment, and participated in several books. He has won the Outstanding Young Teacher Award of the Ministry of Education, two third prizes of the Ministry of Health and Sichuan Science and Technology Progress Award, one second prize of national teaching achievement, and one first prize of provincial teaching achievement (both ranked first). More than 80 papers were published, and SCI included papers 10.

Professor Shi Bing is a national candidate for the "100 Million Talents Project" in the new century, a leading figure in science and technology in Sichuan Province, a member of the Standing Committee of the Oral and Maxillofacial Surgery Committee of the Chinese Stomatological Association, the head of the national cleft lip and palate research group, the head of the southwest and northwest expert group of china charity federation Smile Train, the editorial board of standardized teaching materials for oral and maxillofacial surgery of the Ministry of Health, Chinese Journal of Stomatology, International Journal of Stomatology, China Stomatology Yearbook, Huaxi Stomatology Journal and Practical Stomatology Journal.