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Are high and low eyes obvious in real life?
Obviously.

High and low eyes are a kind of strabismus, not at the same horizontal line, also called vertical strabismus.

High and low eyes are the manifestation of vertical strabismus. According to different causes, it can be divided into congenital strabismus and acquired strabismus. Congenital is usually caused by congenital anatomical abnormality or neuromuscular paralysis.