Although most people think that they brush their teeth carefully and pay attention to oral hygiene, dental caries will inevitably occur. At this time, we will go to the dentist, and the dentist will help us fill our teeth. The so-called tooth filling is simply to remove the decayed part of the tooth and then fill the cavity with some other substances, and these fillers are usually amalgam.
Many people should be psychologically prepared to accept dental drilling, and the most annoying thing is that filling teeth may not be done once and for all, because these amalgam fillings are at risk of falling off. In fact, most people who have filled their teeth have experienced the loss of fillings, so we should shout out, stop filling teeth and let them regenerate.
Dental filling began in the19th century, and today in the 2 1 century, we are still filling our teeth. What is even more outrageous is that there is no essential progress in both technical means and materials for filling teeth. The most annoying thing is that the fillings used for filling teeth have the risk of falling off from beginning to end.
In fact, there is no way. The filling is not a natural tooth, so it can't be perfectly combined with the tooth, and there is a risk of falling off anyway. Therefore, to stop falling off and filling teeth, it is necessary to regenerate teeth. Is this possible? Of course, there are many researches on tooth regeneration at present, the first is stem cell regeneration. There are some soft substances deep in our teeth, which are covered with nerves and blood vessels. They are called dental pulp. There are a lot of stem cells in dental pulp, which is the cornerstone of tooth regeneration.
The research team from King's College London is very interested in a drug called Tideglusib. They found that using this drug can activate stem cells in dental pulp and generate new bone tissue, which is what we usually call dentin.
These regenerated dentin can replace amalgam fillings used to fill cavities. More importantly, they are teeth themselves, so they can blend perfectly with the original teeth and will not fall off at all. Fortunately, the human testing of related research is about to begin.
In the study of dentin regeneration, stem cell regeneration is relatively mild, and there is a more radical method called laser stimulation. Scientists from the University of Buffalo in new york are leading the research on laser stimulation. They don't do it? Try to activate dental pulp stem cells with drugs, but directly stimulate dental pulp with low-power laser.
Under the stimulation of laser, stem cells in dental pulp will regenerate new dentin.
Regenerating dentin by laser stimulation can not only replace the original filling treatment, but also change the existing root canal treatment methods. When the dental caries are too serious and spread to the pulp, root canal treatment is needed, that is, most teeth are pulled out, amalgam fillings are used to fill the gaps, and finally artificial crowns are made to cover the teeth.
This method has the same disadvantage as filling teeth, and the filler will fail and fall off. By stimulating the regeneration of dentin by aurora to fill the vacancy of teeth, the risk of filling falling off can be avoided, and then the crown will be more firm and durable. Whether stem cell regeneration method or aurora stimulation method, its essence is to activate dental pulp stem cells in a specific way, so as to regenerate dentin to fill the gap of caries. So is there any way to regenerate the whole tooth? Yes
The research on direct regeneration of whole teeth has actually been successful in animals. This method is very simple. First, stem cells are obtained from embryos, then a tooth primordium is made from embryonic stem cells, and then the tooth primordium is implanted into the missing tooth, and then the tooth primordium will grow into a complete tooth.
? Why do you want to get stem cells from embryos? Because embryos are the only cells that can make teeth, adult teeth cannot regenerate because there are no embryonic stem cells. This is also an obstacle to the whole tooth regeneration, because obtaining stem cells from embryos will face moral and legal problems, which is insurmountable. Therefore, if you really want to achieve whole tooth regeneration, you should try to bypass the embryo. Embryonic stem cells are the only known stem cells that can generate teeth, but there may still be some unknown parts that allow us to bypass embryos. When the whole tooth regeneration can really come out, it is time for us to bid farewell to the problem of dental disease completely. # There's science every day #