The main factors affecting embryo development and causing cleft lip and palate deformity are genetic factors and environmental factors.
hereditary factor
About 20% children with cleft lip and palate show genetic factors, and there are similar deformities in their direct or collateral blood relatives, and this heritability can be changed due to changes in living conditions or metabolic variations, and it is not invariably passed on to future generations.
environmental factor
malnutrition
In the first three months of pregnancy, pregnant women are malnourished due to pregnancy reaction, anorexia, chronic diseases, indigestion and other reasons, thus affecting fetal development.
virus infection
Many babies born to pregnant women with rubella in the first three months of pregnancy suffer from cleft lip and palate. In addition to rubella virus, pregnant women infected with other viruses can also lead to congenital malformation of babies.
other
Fetal trauma during pregnancy; Long-term hypoxia in early pregnancy; Pregnant women take certain drugs that affect metabolism. Poisoning by certain chemicals can also lead to fetal congenital malformation.
In addition, there are mental factors, especially strong mental stimulation, which may lead to fetal malformation.
(Special note: cleft lip and palate repair surgery belongs to the scope of tertiary surgery and needs to be performed under general anesthesia. According to Article 14 of the Administrative Measures for Grading Surgery in Medical Institutions (Trial) issued by the General Office of the Ministry of Health, when patients undergoing elective surgery need general anesthesia (including basic anesthesia) or blood transfusion, their operation level will be upgraded by one level accordingly. When the pre-anesthesia assessment (ASA) is above Grade III and requires general anesthesia support, the operation should be carried out in a tertiary hospital or a second-class first-class hospital approved by the provincial health administrative department, and some fourth-class operations should be carried out. Cleft lip and palate repair can be performed in the only tertiary surgical hospital in Shandong Province (Jinan Han Plastic Surgery Hospital), which provides security in medical equipment, medical environment, surgical instruments, medical resources and nursing care.