Hyaluronic acid is one of the most popular injectable cosmetic materials. It is widely used in injection wrinkles, replenishing moisture, filling depressions, and even rhinoplasty and breast augmentation. So how is this material produced? Netizen: Hyacinth Plastic Surgery Hospital: Hyaluronic acid is one of the most widely used injectable cosmetic materials. The production process and technology of hyaluronic acid determine its quality. Therefore, products must be produced from regular sources to have therapeutic effect. . Generally speaking, there are three methods of refining: 1. Animal tissue: The main raw materials are chicken combs and cow's eye vitreous body. Degrease and dehydrate the raw materials with acetone or ethanol, soak in distilled water, filter, then treat with sodium chloride aqueous solution and chloroform solution, then add trypsin and keep it warm to obtain a mixed solution, and finally use an ion exchanger to process and purify to obtain refined hyaluronic acid . The extraction rate of this method is extremely low, only about 1%, and the separation process is complicated, making hyaluronic acid expensive, reaching US$5,000/kg, which limits its large-scale use in cosmetics. 2. Microbial fermentation: using glucose as the carbon source fermentation liquid. Ferment in the culture medium for 48 hours. After the fermentation is completed, filter to remove mycelium and impurities, and then use simple operations such as alcohol precipitation to obtain a high-purity product. The advantage of hyaluronic acid produced by fermentation method is that the molecular weight can be set according to product design. The key to the fermentation method lies in the selection of bacterial strains. Currently, Streptococcus, Lactococcus, etc. are mostly used. 3. Chemical synthesis: using natural enzyme polymerization reaction. First, a polysaccharide polymer is used to synthesize the "hyaluronic acid oxazelene derivative", then a water-splitting enzyme is added to create a complex of the derivative and the enzyme, and finally the enzyme is removed in a 90-degree Celsius reaction solution , to synthesize hyaluronic acid. The manufacturing cost of hyaluronic acid can be greatly reduced by artificial synthesis, but the structure is less pure. The expert team of our hospital has accumulated rich clinical experience in treatment. Thanks to word-of-mouth spread among recovered patients, our reputation has spread far and wide, and patients from all over the country have come for treatment. Your best choice. For more knowledge about plastic surgery, you can consult an online doctor.