Acne is also called acne, and the occurrence of acne is closely related to factors such as excessive sebum secretion, blockage of sebaceous glands in hair follicles, bacterial infection and inflammatory reaction. After entering adolescence, the level of androgen, especially testosterone, rises rapidly, which promotes the development of sebaceous glands and produces a lot of sebum. At the same time, the abnormal keratinization of sebaceous gland ducts in hair follicles causes duct blockage, sebum excretion disorder and keratin plug, that is, micro-acne. Many microorganisms, especially Propionibacterium acnes, proliferate in hair follicles. Lipase produced by Propionibacterium acne decomposes sebum into free fatty acids, and at the same time chemotaxis inflammatory cells and mediators, eventually inducing and aggravating inflammatory reaction.