Generally, the nostrils will not get bigger and bigger, because the nostrils are mainly composed of soft tissues with alar cartilage and nostrils. Its size is determined by genetic factors, not by nature. Individual patients may have the possibility that their nostrils will become bigger after picking them. Clinically, there are generally the following possibilities: First, some patients may repeatedly pick their noses, leading to chronic eczema of nasal vestibule. Long-term chronic eczema may lead to thickening of nasal skin and enlargement of nostrils. Generally, patients should not pick their nostrils and apply some anti-allergic ointment locally to reduce the onset of eczema. Second, some patients have recurrent folliculitis and boils on their noses. Repeated boils on the nose are infected, festered and suppurated, leading to local skin hyperplasia and enlarged nostrils. Generally speaking, local inflammation is actively controlled, antibiotic ointment is applied locally, and antibiotics are taken orally. Usually, bad factors such as spicy stimulation and staying up late to get angry are avoided. Third, some patients have rosacea, which is manifested by the proliferation of some vegetation on the alar and the enlargement of the nose. It is generally recommended to go to dermatology for symptomatic treatment, and some patients can also take surgical laser treatment.