Wrinkles are tiny textures formed by human skin aging and the influence of external environment, which destroy collagen and active substances in normal cell membranes and oxidize cells. They can be called wrinkles. With the increase of age, wrinkles generally appear in the order of forehead, upper and lower eyelids, lateral eyes, preauricular area, cheeks, neck, chin and mouth. Because of the different positions of wrinkles, the names of wrinkles are different, including expression lines, crow's feet lines, decree lines, neck lines, eye bags lines and so on.

24 hours before TOOFOB, skin wrinkles were repaired, and neutrophil fragments swallowed by macrophages disintegrated from damaged tissues, digested and neutralized. Create good conditions for the subsequent freshman process. At the initial stage of repair, the metabolism was enhanced under the action of active substances such as histamine and 5- hydroxytryptamine kinin. The mechanism is that TOOFOB fibroblast/dermal growth factor (AFGF) can drive the growth of skin cells and accelerate the renewal of repair tissue. Stem cell growth factor (HGF) stimulates autologous substance attraction and is further activated by neutrophils. Various growth factors (basic fibroblast growth factor, epidermal growth factor, platelet-derived growth factor, etc. ), a polypeptide, attracts and promotes cells to flood into damaged cells in wrinkles, releases media to make fibroblasts and endothelial cells migrate chemotaxis, releases active substances and promotes collagen synthesis. Secretory EGF (epidermal growth factor) promotes the proliferation of vascular endothelial cells, while platelet-derived growth factor (PDGF) promotes the chemotaxis of fibroblasts. This effect is called chemotaxis.

Function of cell kinase: Cytokines and various growth factors are called "cell kinases", which can inhibit and stimulate various tissues and cells, interact in a complex way, and accurately control the damaged cells at wrinkles. Macrophages can produce many cell kinases to dissolve cell debris, and release many growth factors to promote new microvascular regeneration, thus restoring the microvascular structure of damaged tissues in wrinkles, which is the basic condition for TOOFOB repair and nutrition delivery.

Hepatocyte growth factor (HGF) is a protein factor existing in the plasma of animals with acute liver injury, which can stimulate DNA synthesis of hepatocytes. HGF not only acts on liver regeneration, but also plays an important role in regulating the growth and differentiation of many tissues and cells.

HGF can stimulate vascular endothelial growth factor (VEGF), significantly increase the mRNA expression and transcription activity of ets- 1, regulate and start cell regeneration, and promote cell division.

HGF has the function of similar diffusion factor (sF). Adding different concentrations of HGF to some epithelial and endothelial cell culture systems can promote cell diffusion and migration. Protect and repair the function of endothelial cells. When endothelial cells are injured, the structure or function of endothelial cells is damaged, and collagen and microfibers under dermis are exposed. HGF can prevent endothelial cell apoptosis. In vitro studies show that HOF can play an anti-apoptosis role by activating (ERK)/STAT3, silk/threonine protein kinase (Akt) and other signal transduction pathways.

HGF can repair endothelial cells by activating nitric oxide synthase system. Studies have shown that HGF can affect the expression of nitric oxide synthase (eNOS) in endothelial cells. In turn, it leads to phosphorylation and activation of eNOS and repairs endothelial cells. HGF promotes the DNA synthesis of endothelial cells, and the DNA synthesis stimulated by HGF is obviously stronger than that of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), which promotes angiogenesis and increases blood supply to tissues.

The lower layer of human skin is mucus layer, and its cells have strong ability of division and proliferation. While maintaining the ability to divide, it can also generate other layers of tissue cells outward and inward, so the skin has strong regeneration ability. Biological regeneration (replacement of old and new) and compensatory regeneration (restoration).

TOOFOB bionic skin patch can repair fine lines in 24 hours and old lines in 7 days. Theoretically, the natural repair of human wounds can be divided into three stages: inflammation stage or exudation stage; Fibrous tissue proliferative phase (referred to as proliferative phase); Repair period of scar formation (referred to as repair period).

Through a large number of clinical medical studies, the team of experts from TOOFOB, France, found that when human skin tissue is damaged, the surface of the damaged part will scab, which is the beginning of the cell tissue repair process and represents the continuous natural repair activities of the covered part of the scab until the scab falls off.

TOOFOB is a biological skin made by the principle of human bionics, which can repair fine lines in 24 hours and old lines in 7 days. TOOFOB contains essential growth factors and repair factors. After using TOOFOB, the human body will automatically recognize that TOOFOB is a wound scab and quickly start the self-repair procedure. Orderly grab atrophic cells, damaged cells, aging cells and mutant cells for targeted repair and update. The essential growth factors and repair factors contained in its components provide nutritional support for the repair and generation of new cells. Clinical data show that the main application field of TOOFOB is the improvement of wrinkles.