Induced pluripotent stem cells were first reported by two Japanese scientists, Gao Qiao Hezhi and shinya yamanaka, in 2006, and the article was published in. Shinya yamanaka finally won the Nobel Prize on 20 12. 20/kloc-in September, 2004, a Japanese patient with degenerative eye disease will become the first person in the world to receive induced pluripotent stem cells (iPS) treatment. 1 induced pluripotent stem cells (iPS cells) were originally a cell type similar to embryonic stem cells and embryonic APSC pluripotent cells obtained by Japanese scientist shinya yamanaka in 2006 by transferring the combination of four transcription factors (Oct4, Sox2, Klf4 and c-Myc) into differentiated somatic cells and reprogramming. By introducing foreign genes, somatic cells can dedifferentiate into pluripotent stem cells, which we call induced pluripotent stem cells (IPS).