Zhang Ming, a plastic expert, said: PRP autologous serum wrinkle removal can last for 9- 12 months. It is usually recommended to receive PRP once a month to rejuvenate autologous cells, and three consecutive injections can maintain the effect for about 3 years. Treatment once every six months to one year can maintain the curative effect for a long time. Therefore, how long PRP autologous serum can keep wrinkle removal at a time depends on how many times you inject PRP.