The discovery of glucan originated from 1870, and then the existence of cross-linked glucan was found in 1950. From 65438 to 0970, it was really used in clinical practice, mainly as plasma infusion and for treating trauma. LICOL dextran filler obtained some national patents in 2007, and related products were successfully developed in 20 10, 20 12, 20 14 and 20 15 years. It is undeniable that it is indeed a safer filler and has been recognized.