Cell growth factor is a kind of small molecular active polypeptide which can promote cell renewal and regeneration and participate in human life activities. Epidermal cell growth factor (EGF), fibroblast growth factor (FGF) and keratinocyte growth factor (KGF) are commonly used cosmetics, which are the basic elements to promote the growth of skin cells and stem cells, and are also called the golden factor of human body. Jinan University took the lead in developing recombinant human fibroblast growth factor FGF and recombinant human epidermal growth factor EGF into two new drugs for genetic engineering in the world, and creatively introduced cell growth factor into medical plastic surgery and professional beauty for the first time, creating a precedent for "biological beauty".

In order to solve the technical problems such as unstable cell growth factor activity and difficult transdermal absorption, a number of doctors and professors from the Medical Biotechnology Research and Development Center of Jinan University jointly tackled the problem, and successfully developed a series of "lipstick" stock solution and "lipstick" microemulsion products by using liposome encapsulation technology and microemulsion technology. The products processed by this process have excellent quality, good transdermal absorption, sustained release and strong product stability. Compared with the products processed by conventional production technology, it has unparalleled advantages. The breakthrough of the core technology of cell growth factor won many national patents for technological invention, and the related technological achievements won the National Science and Technology Progress Award (2006) and the National Technology Invention Award (2009). With the method of bioengineering, many kinds of active protein are produced, and its molecules are much less than the protein of egg white, which is called polypeptide. To maintain their activity, they must be stored in the unprotected natural environment, otherwise the oxygen and heat in the air will make them lose their activity and no longer have their functions.

Therefore, a new dosage form, low humidity freeze-dried powder, is adopted to ensure that the vacuum in the bottle is oxygen-free and the water content is 0.

2. Promote product development: the core component is multifunctional bioactive protein.

3. Change the product structure and nursing mode: freeze-dried preparation.

4, single dose packaging, abandon preservatives.

In allergen skin patch test, 70% of contact dermatitis is caused by preservatives. Such as: nickel sulfate, epoxy resin, lanolin, Kabbah mixture, potassium dichromate, magnesium chloride, Kane mixture, quaternary ammonium salt-15, essence mixture, hydrogen sulfide, rosin, p-phenylenediamine, p-hydroxy formic acid mixture, formaldehyde, cobalt dichloride, sulfhydryl mixture, Peruvian balsam, thiomersal, ethylenediamine hydrochloride, Qiu Lan mixture, black.