However, in the 1990s, PRP extraction technology needed to be produced in a large laboratory, which required complex equipment. At the same time, there are also problems such as insufficient growth factor concentration, long production cycle, easy pollution and easy infection. With the continuous development of science and technology, there are many technologies in the world that can quickly generate safe PRP plasma, and the application scope is more and more extensive.

Among them, at the beginning of 2004, two world-famous professors of medical plastic surgery, Dr. Kubota (Japanese) and Professor Otto (British), innovated on the basis of PRP extraction technology to produce ACR plasma rich in high concentration growth factors, rich in EGF (epidermal growth factor) and VEGF (vascular growth factor) that other production methods did not contain. These two growth factors can ensure the remarkable improvement of the skin. The generation of ACR plasma really applies PRP to injection plastic surgery technology, and comprehensively adjusts and regenerates the whole cortex. At present, the innovative ACR technology based on PRP extraction technology has been widely used in developed countries and regions such as Europe, North America, South Africa, the Middle East, Australia, Japan and Singapore.