Yes, but it takes up a lot of memory, and the general computer configuration will run very slowly during the production process. It is better to use PS for such a big picture. Whether the effect of the picture is blurred depends on the resolution of the picture. As long as it is larger, you can set the pixels when creating a new file, and ctrl+n can set the pixels of the new file. The effect picture can be reduced ten times, that is, 30cm× 100cm. If your computer configuration is not too high, you can print a rendering with more than 72 pixels. If your computer has a high configuration, you can print a 150-300 pixel rendering. After the manuscript is booked, you can enlarge the size and reduce the pixels when painting. You can draw with 20 or 25 pixels. Generally speaking, it's ok from a distance, but it's definitely blurred from a close look.

Then, if the original material is fine and not demanding, design with a resolution of 300 at the ratio of 10%, and enlarge the viewing effect by 10 times in PS. If it is not ideal, it is necessary to increase the scale or design according to the actual size. This puts forward higher requirements for the performance of the computer. Then ask the advertising store to output at 300 resolution. Generally, large posters and advertisements are made of coreldraw vector images, and the resolution of the bitmap can be 36~72dpi. It is required that the pixels of the bitmap should be as large as possible. After exporting the finished product, check whether the image in bitmap position can meet your requirements.