First, environmental factors. It is also related to nutrition, heredity, infection, endocrine and other factors.
1, virus infection: such as upper respiratory tract infection of pregnant women, rubella, etc.
2, drug effects: such as taking antiepileptic drugs, lowering cholesterol, anti-allergic, anti-cancer drugs.
3. Endocrine: mental or traumatic factors, such as intense mental stimulation and trauma.
4, nutritional factors: vomiting in the first trimester, anorexia, partial eclipse, etc. Lead to vitamin D, folic acid, iron, calcium and other deficiencies.
5. Other factors: such as X-ray exposure, smoking, excessive drinking and lack of oxygen.
Second, genetic factors. A considerable part of cleft lip and palate is hereditary, and the incidence of cleft lip in immediate family members is about 4%. Generally, the probability of cleft lip and palate in the first child is 1/600. If the first child is cleft lip and palate, the probability of cleft lip and palate in the second child is 3/ 100.
Normal fetus, after the fifth week, began to gradually merge with some embryonic processes to form a face. If it can't develop normally, it can be deformed, including cleft lip. The incidence is about 1: 1000.
Extended data:
It is generally believed that unilateral cleft lip surgery is suitable for about three to six months, while bilateral cleft lip is a little later. The basic conditions for children to adapt to surgery are: general health, no upper respiratory tract infection, and no infection in local and surrounding tissues.
Pregnant women should avoid partial eclipse during pregnancy, ensure adequate intake of vitamins B, C, D, calcium, iron and phosphorus, keep a calm mind, avoid mental stress, do not take anti-tumor drugs, anticonvulsants, histamine drugs, Keminjing and some sleeping pills for morning sickness, do not smoke or drink alcohol, and avoid exposure to radiation and microwaves.
References:
Baidu encyclopedia-cleft lip