Now we all know that Chang Gung Memorial Hospital has a dermatologist who specializes in drug allergy. The dermatologist has a medical team composed of a group of enthusiastic doctors. Text/? Photo courtesy of Wu Peifen/The Drug Allergy Center in the North Campus of Chang Gung Memorial Hospital was started by a group of interdisciplinary hematologists in Chang Gung Memorial Hospital. For the purpose of medical research, they sincerely gather together to help patients and solve various incurable diseases that may occur after taking medicine. This lasted for 7 or 8 years, and this group of doctors accumulated a certain tacit understanding. Wang Zhengyi, former president of Linkou Chang Gung Memorial Hospital, witnessed this situation and said, "Why don't we just set up a center?" It turns out that Zhong, a dermatologist attending Chang Gung Memorial Hospital who just wanted to study Stevenson's syndrome related to dermatology, and a group of like-minded doctors, under the active promotion of Yang Zhixun, dean and director of dermatology, established the first drug allergy center in Taiwan Province Province, and Zhong Ziran was appointed as the director of this cross-hospital and cross-professional drug allergy center. From allergic skin rash caused by drug abuse to anaphylactic shock caused by injecting * * * substances, as long as it is an allergic problem caused by drugs, everyone will think of Chang Gung Drug Allergy Center. Now, this interdisciplinary team will take the initiative to hold regular meetings every month to conduct interdisciplinary consultation and discussion on the patient's condition. Chang Gung Drug Allergy Center was established in June, 20 1 2008. It is a medical team of China 1 drug allergy, which takes patients as the center and provides holistic care. Interdisciplinary team members include dermatology, neurology, gastrointestinal hepatobiliary department, chest department, nephrology department, infectious medicine department, plastic surgery, ophthalmology, pathology and pharmacy. In the ward area of dermatology, three beds are planned, which are exclusive beds for patients with drug allergy. But many patients are so serious that they will go to the intensive care unit as soon as they are admitted to the hospital. Zhong said that drug allergy centers have specialized laboratories and similar specialized laboratories, and only advanced countries such as Japan and Canada have such equipment and services. The testing services provided by the laboratory include drug application test, in vitro immune activation test of allergic drugs and genetic testing. As far as surgical shock is concerned, it may be caused by * * * agents, muscle relaxants or antibiotic allergies used in surgery. As many as 65,438+00 * * formulas may be used in one operation. What kind of drug caused anaphylactic shock? The in vitro immune activation test of allergic drugs needs laboratory researchers, drug-specific antibodies and anaphylactic shock identification equipment to find out the drugs that cause allergies. Zhong said that once the operation appears shock, it is necessary to stop the operation and find out the allergen. Otherwise, the patient's blood pressure will continue to drop and the patient's vital signs may disappear at any time. The medical staff are also very anxious and don't know which medicine to stop. One of his patients went into shock three times in a row before he found the drug that caused the allergy. Gene detection is related to the discovery of many drug allergy genes in recent years. From the research topic that residents should be promoted to attending doctors, Zhong locked Stevenson's drugs for epilepsy caused by Johnson & Johnson syndrome. He said that Chang Gung Memorial Hospital receives 1 to two inpatients with Stevenson Johnson & Johnson syndrome every week. He looked through foreign literature and found that general hospitals abroad need 3-5 patients with severe drug allergy 1 year. Many foreign medical staff visit Chang Gung Memorial Hospital and treat as many as 50 patients with severe drug allergy a year. They were all shocked to see such data. Zhong began to actively collect patient data and study this subject in depth. In 2004, Zhong of China Academy of Sciences and his research team contributed to the internationally renowned journal Nature. After seeing so many patients, auditors also suspect that the data is fraudulent. After verification, it was published in April of the same year. This is the first paper published in the journal Nature and published by the local research institute of Taiwan Province Province, and it is also the first paper in the world to prove that drug allergy is related to genes. The content of this paper is "Stevenson syndrome caused by carbamazepine is strongly related to HLA-B * 1502 in Han nationality". After the publication of the paper, some foreign experts in the same field, like the reviewers of Nature, initially questioned the local research in Taiwan Province Province. RegiSCAR (mostly composed of dermatologists, with textbooks recording the definition of severe drug allergy, mostly from members of the alliance) invited Zhong to join the organization's case registration system, requesting to re-examine whether China's cases meet foreign diagnostic standards. As soon as Zhong receives the patient, he should inform the European Drug Allergy Union. This paper has been cited more than 500 times so far. Zhong said that after the publication of the paper, he had no time to think about medical beauty, so he was dragged into the medical field of drug allergy by a series of drug research projects and patients. Even relevant medical research institutions abroad have taken the initiative to find Zhong to cooperate and give a speech. In 2008, another research paper of Zhong was published in the journal Nature Medicine. The content is to find the deadly toxic protein released when the skin is ulcerated, and the immune cell T cells are activated to attack the skin. Some people have been studying Nature all their lives, but Zhong published two articles in Nature in five years. Will there be a third one? Zhong smiled and said, "There is a lot of pressure! Now we all know that Chang Gung Memorial Hospital has a dermatologist who studies drug allergy. The dermatologist has a medical team composed of a group of enthusiastic doctors. Zhong said that the number of patients in his drug allergy clinic has exploded, and each patient has brought a pile of information for him to judge whether there is a drug allergy problem. Zhong said that many patients are confused about the side effects after taking the medicine, and now they all come to him. His patient base is not limited to skin problems. Some patients will take the initiative to take a pile of surgical materials before surgery, and ask the center to test whether there are allergic doubts before they dare to operate. Sometimes, Zhong must testify in court in medical dispute cases to prove that the patient has drug allergy; Occasionally, I have the obligation to help patients fill out a love letter about drug injury and apply for drug injury relief. In the process of helping others, Zhong also found the shortcomings of medical regulations. He said that there was an academic exchange at Chang Gung Memorial Hospital in February, 2000, by the Drug Relief Officer/KLOC of the Japanese Ministry of Health and Welfare. According to these officials, the passing rate of medical injury applications in Japan is as high as 90%, which is higher than 50% in Taiwan Province Province. When trying a case, the Japanese Drug Injury Review Board will focus on the patient's position, and when it comes to the gray area of the trial conditions, it will pass relief as appropriate. Zhong said that most of the patients he met who were injured by drugs belonged to relatively weak ethnic groups. These patients have to face the harm of the primary disease and endure the possible side effects of drugs, which is really hard. In Taiwan Province Province, when encountering medical disputes, most patients will blame the medical staff. In Europe and America, pharmaceutical companies have to pay compensation, which is a link that people in Taiwan Province Province seldom pay attention to when facing medical disputes. Now, Zhong has been recruited as a member of the Drug Injury Relief Committee of the Department of Health. This development was unexpected when Zhong entered the Chang Gung medical system. At the beginning, I entered the dermatology department under the embrace of fate, but I gave up commercial medical beauty, entered an unpopular drug allergy, and even had to deal with medical disputes. Zhong said that he is often caught between patients and doctors in the same industry, and the pressure is really great. He can only deal with it according to his profession. The 1 meeting of drug allergy patients was held in April this year, with more than 70 participants. Many patients shared their experiences. In the end, some patients cried, and he felt sorry for them. Zhong pointed out that there are many drug harm relief groups composed of patients abroad, such as Stevenson Johnson Syndrome Foundation, many of which are lawyers. He also hopes that enthusiastic lawyers will stand up and help patients fight for their rights and interests. Team members /24 interdisciplinary attending physicians, 3 pharmacists, 1 case manager, 2 assistants This article is taken from 356 issues.