An explosion occurred at the headquarters of Dai Dallos, a well-known pharmaceutical company. A teenager was trapped in a collapsed steel frame and his life was dying. At this time, in the case of not pursuing unlicensed medical practice, Black Jack performed a "surgery" that no one could imagine. The same disaster triggered another tragedy: a mother was seriously injured and paralyzed. In order not to drag the child down, she sought the euthanasia of Dr. Chilico, known as the incarnation of death. On the other hand, in order to save his mother, his children worked hard day and night to save money, hoping that Black Jack would operate on his mother. Looking at their figures, Black Jack unconsciously remembered his own experience. Two doctors, one dying and the other saving lives. On Icarus' secret island, Black Jack and Chirico will launch a life-and-death collision confrontation. What was the inside story of the explosion? The biggest crisis in the history of this series is approaching this talented surgeon step by step!