After injection of botulinum toxin, local adverse reactions mainly include myasthenia gravis and the corresponding manifestations caused by the spread of botulinum toxin to adjacent muscle tissues, and these clinical manifestations are related to the injection site and the dose of botulinum toxin. A few patients found symptoms such as fever, discomfort and fatigue after injection of botulinum toxin. Generally speaking, these clinical manifestations are short-lived and disappear on their own within a few weeks. After injection of botulinum toxin, the general effect can be maintained for about one year, and then there is the possibility of recurrence, but it can be injected again. ?