APSC pluripotent cells +SVF autologous fat facial filling is to collect primitive cells with self-replication and multi-directional differentiation potential through tissue cells, and then to fill/wrinkle/shape the proliferated APSC adipose pluripotent cells and fat in layers and at multiple points through micro-needles. Pluripotent cells can promote cell maintenance and regeneration, restore cell activity, restore vitality, restore young appearance, and truly achieve the goal from the inside out. Facial filling with APSC pluripotent cells and svf autologous fat is a leap in facial micro-plastic. This technology extracts, digests, cultivates, subcultures, labels SVF-activated cells from high-purity adipocytes, and then fuses them with high-purity adipocytes for the second time, thus constructing a complete cell nutrition supply system in isolated adipocytes and steadily improving the survival rate of adipocytes to over 90%.