Antihistamines are the first choice for the treatment of urticaria, which are divided into the first generation and the second generation. The representative drugs of the first generation are ketotifen, cyproheptadine and chlorpheniramine. There are many second-generation antihistamines, such as cetirizine, desloratadine, fexofenadine, ebastine, mizolastine and so on.

Glucocorticoids can be used in patients with acute systemic urticaria or patients with allergic shock tendency, such as prednisone, dexamethasone, methylprednisolone, etc. And pay attention to monitoring the adverse reactions and side effects of drugs when using them. Vitamin C and calcium gluconate can reduce capillary permeability, relieve edema and itching symptoms, and can also treat acute urticaria. Other antiallergic drugs such as compound glycyrrhizin tablets, Yupingfeng granules, Xiaofeng Zhiyang granules and urticaria pill can also treat acute and chronic urticaria.