Which is more effective in removing wrinkles, hyaluronic acid or botulinum toxin? Botulinum toxin: The first step of botulinum toxin injection for wrinkle removal is that the toxin binds to neurons and then enters the cytoplasm of nerve cells. Finally, the toxin inhibits the action of acetylcholine on the neuromuscular connection and paralyzes the muscles. This is called neuromuscular denervation. However, during the process of botulinum toxin taking effect, the body will also have certain reactions. Hyaluronic acid: This is a high-molecular polymer hyaluronic acid, which not only lubricates joints, but also regulates the permeability of blood vessel walls and the diffusion or movement of proteins, water and electrolytes, and ultimately promotes wound healing. Comparison of effects: One hyaluronic acid wrinkle removal injection can last for about 6 to 12 months. If you are not satisfied with this time, you can just make up for it when the time comes. At the same time, hyaluronic acid is also a very safe material for external filling materials in medicine. As long as time is up, it can be excreted with metabolism. Although Botox is highly effective in removing wrinkles, it has relatively few side effects. However, the anti-wrinkle power of Botox will slowly spread to local muscle tissue, causing muscle weakness near the injection site or causing eyelid drooping, but it can only last for one to two weeks.