With the passage of time, aging is a spontaneous and inevitable process. The physiological changes in the process of human aging are mainly reflected in a series of irreversible decline, such as the loss of tissues, cells and components, the slowdown of metabolic rate, and the decline of body and organ functions. Including memory loss, slow response, decreased exercise ability, decreased secretion of related hormones and other organ degeneration, as well as external manifestations such as senile plaque, skin wrinkles, sparse hair and whitening. Aging is inevitable, but it may delay it. Cell is the basic unit of organism structure and function, and the aging of organism is the aging of cells in the final analysis. The reconstruction and regeneration of somatic cells is the most fundamental way to resist aging, so stem cells with multi-directional differentiation and value-added ability are well-deserved choices. Anti-aging, this time starting with stem cells. Stem cells make you no longer afraid of aging. 0 1 Functional cells, stem cells, and cells in the aging human body are mostly terminally differentiated cells, which have no ability to divide again and will eventually die of aging; But at the same time, some undifferentiated primitive cells, that is, stem cells, remain in the body. Stem cells produce new stem cells or differentiate into new functional cells under certain conditions, thus maintaining the dynamic balance between the growth and decline of tissues and organs. When the process of decline is greater than the ability of re-growth, it shows aging. The persistence of stem cells in the body makes them vulnerable to the accumulation of toxic metabolites related to aging. With the increase of age, stem cells in many tissues undergo profound changes, and eventually cell death, aging or loss of regeneration function occur, which is manifested in the slow response of the aging body to tissue injury, unbalanced proliferation activity, and decreased cell renewal and tissue regeneration functions. If the number of young stem cells in the body increases, the process of tissue aging will be delayed or even blocked. Studies have confirmed that injecting the blood of young people, drugs that limit calories or prolong life into the aging body can also enhance the stem cell function of the aging body to a certain extent, so that the aging body presents a younger cell state. On the one hand, this method needs enough high-quality endogenous stem cells, but it is difficult for aging organisms to meet the standards; Secondly, just as the repair of damaged DNA needs to identify the main regulatory genes and autophagy of cells must be selectively controllable, there is still a long way to go to achieve anti-aging effect through the intervention of endogenous stem cells due to the complexity of mechanism and implementation means. Another direction of stem cell anti-aging-using exogenous stem cells to correct the aging problem of the body has been widely studied and applied. At present, a large number of anti-aging stem cells have been studied, and it is found that stem cells exist in the whole life process of the body, which has the functions of antioxidation, anti-wrinkle and promoting wound healing. Experiments show that dermal pluripotent stem cells (DMSCs) can prevent skin aging by increasing the level of type I collagen and skin thickness, and can increase the number of skin precursor cells and the ability of epidermal regeneration together with dermal stem cells (DSCS). Therefore, it is easier to achieve anti-aging by using exogenous stem cells for the following reasons: ① The mechanism of action is simple and controllable: at present, there are two kinds of transplantation methods: intravenous infusion and local transplantation (filling); ② The number of transplants can be controlled; ③ The effect is obvious. Anti-aging effect of exogenous stem cells The anti-aging mechanism of stem cells is comprehensively described above. The function of stem cells on human body is to improve the overall body function, improve sub-health and delay aging. At the same time, the physiological differences between men and women can be intervened according to the local physical condition. 1 Improve body function as a whole. Exogenous stem cells enter the body through veins and are transported to many parts of the body with blood, thus improving the metabolic capacity of the body as a whole and improving the sub-health state. On the other hand, aging leads to the decline of immune cells, activity and disease resistance, so diseases such as tumors are prone to occur. Exogenous stem cells can secrete a variety of effective components after implantation and regulate the immune system of the body. Anti-aging beauty female beauty, enhance skin elasticity, prevent wrinkles; Improve women's menstrual problems; Postpone female menopause, improve menopausal syndrome and delay aging; Promote * * * and restore sagging * *. 3. Improve physical strength and energy for men's anti-aging and improve the overall function of the human body; Speed up thinking and reaction ability; Improve sexual function; Improve prostate problems; Eliminate obesity and beer belly. Disease treatment uses the ability of stem cell proliferation and multi-directional differentiation to regenerate new tissues and organs, rather than damaged and decayed tissues, so as to fundamentally achieve the purpose of treating diseases and delay the aging of the body. At present, the fields involved in stem cell therapy include: immune system diseases, nervous system diseases, inflammatory diseases and tissue regeneration. Selection of stem cells Exogenous adult stem cells that can be used for anti-aging mainly include oral stem cells, adipose stem cells, bone marrow mesenchymal stem cells and mesenchymal stem cells derived from pregnancy tissues; Mesenchymal stem cells are widely available and do not involve ethical issues, and have become the most studied and applied stem cells in the world. Since it is anti-aging, the young level of stem cells is particularly important. There are many kinds of stem cells mentioned above that can be used for anti-aging, but not all of them are the best choice in terms of youth and activity. Oral stem cells, which have been widely studied in recent years, not only have outstanding performance in treating diseases, but also are most suitable for anti-aging fields. Oral stem cells (dental pulp stem cells of deciduous teeth) were taken from deciduous teeth of children aged 5- 12. Children are still young, so stem cells in the body are also the youngest and most active. Experiments show that the number of stem cells extracted from the same amount of dental pulp and bone marrow is dozens of times that of the latter, and the activity is far ahead. In addition, it also has the excellent characteristics of convenient materials, low immunogenicity and no need for matching when using. (Comparison of the number and activity of dental pulp stem cells DPSC and bone marrow stem cells BMSSC) The anti-aging mechanism of oral stem cells is to differentiate into a variety of functional cells to replace aging or damaged cells and tissues. Oral stem cells that secrete cytokines can also secrete cytokines through secretion, promote regeneration and repair tissue damage. Oral stem cells that promote collagen synthesis also participate in the synthesis of collagen in fibroblasts and promote skin regeneration. Some in vivo studies have confirmed that stem cells can improve and increase the thickness and density of aging skin and collagen fibers, and reduce skin wrinkles. Anti-inflammatory oral stem cells also show great prospects in the application of immunomodulators. Some animal studies have shown that intravenous injection of oral mesenchymal stem cells can reduce the pro-inflammatory reaction. Anti-aging, longevity and immortality are eternal topics, but few people succeed. The ancients tried a panacea and "Tang monk meat" for us. With the continuous progress of society, the mechanism of aging is gradually clear, and people's methods are more mature. Stem cell therapy is widely used in cosmetic and plastic surgery because of its repair and regeneration ability. It is an excellent candidate for regenerative medicine and will be the mainstream of anti-aging cell therapy in the future. Oral stem cell bank guarantees the health of thousands of families! 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