The first episode took place eight weeks after Wilson's girlfriend died. Obviously, under this blow, he has lost interest in life. No matter how busy the hospital is and how House stimulates him, he is completely depressed. In the face of such a living dead person, when House encounters difficulties or needs to share all kinds of good ideas or bad ideas with others, who should he throw himself into? Fortunately, this question was answered in the second episode-the emergence of private detectives forced House to have a like-minded partner. This man, played by michael weston, is said to be almost as cunning and evil as Dr. House himself.

In the past four seasons, House has guided an elite team of young experts to help him solve intractable diseases. His good friend, oncologist james wilson, was loyal to him. At the same time, LisaEdestein, director of the medical department and head of the hospital, also had an affair with House. Although House often conflicts with her because of her responsibilities and her whimsical behavior, even so, she has to admit that House is smart enough to offset his troubles. In the fourth season, the opinionated House selected 3 out of 40 applicants and matched a large number of new people for his diagnosis and treatment team. He chose Dr. Chris Tao Bo, a plastic surgeon (Peter Jacobson), Dr. Rema Hadley, a charming contestant (olivia wilde) and Dr. Eric Foreman, a neurologist (omar epps). The passionate and radical Dr. Lawrence Koutna (Carpan) makes arrangements for him-in fact, he is Cody's eyes in House.

Former members of the Four Seasons Team, immunologist Dr Allison Cameron (jennifer morrison) and intensive care doctor Dr RobertChase (Jesse Spencer), will not continue to respond to House's call. Cameron was promoted to the emergency medical center, while Chase went to Princeton Plain Teaching Hospital. At the end of the fourth season, a bus had a serious accident. In a memory of being four hours late, Dr. House and his team pieced together their own memories, and finally found that Wilson's girlfriend Amber was in the same car with him and was seriously injured. When Dr. House and his team were racing against death for Amber, they found that there was nothing they could do about the obvious deterioration of Amber's condition. I was surprised to learn that House was directly related to Amber's death, and the bridge of friendship between Wilson and him collapsed.

At the beginning of the fifth season, with the friendship shattered by Wilson, House is determined to find out whether he is responsible for Amber's death. Meanwhile, as Cody tries to mediate between them, Wilson will decide whether House ruined his life.