Because the whole face is filled with a large amount of hyaluronic acid, there will be more pinholes in the face, so the probability of bacteria or viruses entering the skin through pinholes will increase. Once infected, if it is local oral antibiotics, if the infection spreads to the whole body with blood, patients will have fever symptoms and need intravenous antibiotics. 2, vascular embolism, because there are many points to inject hyaluronic acid into the whole face, it is possible to inject hyaluronic acid into the blood vessels during the operation, the blood vessels will be blocked due to ischemia, the tissues at the blood supply site will be affected, the local skin may be black, and the patient will feel pain. If injected into a large blood vessel such as ophthalmic artery, the patient may become blind immediately. 3, local skin depression or protrusion, due to the whole face injection, the absorption speed of hyaluronic acid in different parts is different, some places absorb fast, and some places absorb slowly, which may lead to local small protrusions or depressions.