He has served as teaching secretary, deputy director, department director, teaching and research section director of the affiliated hospital of Qingdao University Medical College, and dean of the affiliated hospital of Brain Medical College. He is currently the vice president of Qingdao Municipal Hospital, director of Brain Center, director of neurology department, director of teaching and research section of neurology department, leader of neurology department, key medical and health college of Shandong Province, member of Neurology Branch of Chinese Medical Association, member of Neurology Branch of Chinese Medical Association, deputy director of Neurology Branch of Shandong Medical Association and chairman of Neurology Branch of Qingdao Medical Association. Evaluation expert of National Natural Science Foundation, editorial board members of domestic and foreign journals such as Alzheimer's Disease Journal, chinese journal of clinical neurosciences Journal, China Stroke Journal and Clinical Neuroelectrophysiology Journal. Reviewers are invited from domestic and foreign journals such as Research on Rejuvenation, Gene, Journal of Clinical Chemistry, Bulletin of Brain Research, Clinical Neurology and Neurology, and Chinese Journal of Neurology.
Professor Tan Lan is the leader of neurology in Shandong Province. He has been a doctor for more than 30 years and has made outstanding achievements in clinic, scientific research and teaching for a long time.
In clinical work, years of conscientious work in the clinical front line, with a high level of clinical diagnosis and treatment. He has accumulated rich clinical experience in the diagnosis and treatment of critical cases and intractable diseases of nervous system. Participated in the rescue of nervous system critical patients such as acute cerebrovascular disease, myasthenia gravis crisis, severe guillain-barre syndrome and status epilepticus for many times, and presided over the discussion and consultation of large-scale intractable diseases for many times. Many patients from home and abroad came to see a doctor, and their superb medical technology and noble medical ethics were unanimously recognized by patients and their families. The first epilepsy clinic was established in Jiaodong Peninsula, and the Qingdao epilepsy diagnosis and treatment center was established, which established the leading position in basic research and clinical diagnosis and treatment of epilepsy in China and was affirmed by domestic peers. In the 2008 Beijing Olympic Games, as a clinical expert in the designated hospital for Olympic medical security, she successfully completed the Olympic security work and won the outstanding contribution award for medical security in the sailing competition of the 2008 Beijing Olympic Games and Paralympic Games. 20 1 1 was rated as an excellent doctor in Shandong province, and 20 12 was rated as a young and middle-aged expert with outstanding contributions from the Ministry of Health.
In scientific research, as the project leader, he presided over more than 20 vertical projects, such as general projects of National Natural Science Foundation of China, key projects of Shandong Natural Science Foundation, projects of leading medical talents in Shandong Province, and projects of Qingdao Science and Technology Support Plan. The correspondent was in N Engl J Med (if: 53.484). More than 200 academic papers have been published in important academic journals at home and abroad, such as Progneurobiol (if: 9.966), neurobiol age(if:6.634), Jalzheimers DIS (if: 4.26 1), Chinese Journal of Medicine, Chinese Journal of Neurology, etc. Among them, 56 papers were included in SCI, with total impact factor. The research results have been cited more than 300 times by internationally renowned journals such as Nature Genetics (IF: 36.377), NAT Revnosoci (IF: 26.483), J mol Cell Biol (IF: 13.4) and ANN Neurol (IF: 9.3 17). He has successively edited Cerebrovascular Therapeutics (People's Health Publishing House in 2000), Medical Biotechnology and Principles (Ocean University of China Press in 2009), Graphic Neurology (Military Medical Science Press in 2006) and Neurotherapeutics (Shanghai Science and Technology Press in 2004), and participated in the compilation of Elsevier, a world-renowned publishing house. In the field of epilepsy research, a large sample personalized drug library of epilepsy in China Han population was established. It was found that the polymorphism of CYP450 enzyme gene and UGTlA6 gene was related to the blood concentration of valproic acid, and the MDR 1 gene and its expression were related to multidrug resistance in refractory epilepsy. It is found that bilateral thalamic nucleus feedback electrical stimulation is more suitable for the treatment of clinically refractory epilepsy, 160Hz, 3V, 10. In the research direction of dementia, a large sample of Han AD genetic and clinical resource database was established. For AD, CLU, β2-AR, APOE, SORCS 1, ADAM 10, MAPT, GSK3β, MOBP, EIF2AK3, TTBK 1, IL- 18, IL-33, TLR2. NEDD9, TFAM, TOMM40, MTHFD 1L, IGF 1 and SLC2A 14 are the susceptibility genes of China Han people, and the genetic polymorphism sites related to susceptibility have been determined, which can be used as genetic markers for early warning and diagnosis of AD in China Han people. Academic achievements won the third prize of Shandong Science and Technology Progress 20 1 1 (No.1). Second Prize of Shandong Science and Technology Progress 20 10 Second Prize of Shandong Medical Science and Technology Progress (1) First Prize of Qingdao Science and Technology Progress 20 1 1 Second Prize of Qingdao Science and Technology Progress 2009 (1)
In teaching, he is currently a doctoral tutor of Qingdao University, China Ocean University and Nanjing Medical University, a cooperative tutor of post-doctoral mobile station of clinical medicine of Qingdao University, and a master tutor of Dalian Medical University, Taishan Medical College and Weifang Medical College. Since 1998, it has trained graduate students in neurology 106, and exported a large number of high-end talents in neurology for China. At present, there are 5 postdoctoral 1 person, 5 doctoral students and 6 master students1person. Postgraduates have successively won more than 20 academic awards, including Shandong Graduate Excellent Scientific and Technological Innovation Achievement Award, Shandong Excellent Master's Thesis, Qingdao University Graduate Excellent Scientific and Technological Innovation Achievement Award and Qingdao University Excellent Master's Thesis.