Currently, there are two types of drugs for the treatment of obstetric cholestasis. Specialized centers for the treatment of obstetric cholestasis tend to use ursodeoxycholic acid, a drug that eliminates or reduces pruritus and normalizes liver function and bile acid indicators. In the treatment of obstetric cholestasis, hormonal drugs (mainly dexamethasone) can also be considered, but pregnant women should be closely observed when using them. At the same time, you can use some anti-itch medicine for external use on the skin, such as calamine lotion.

Because pregnant women with obstetric cholestasis may have postpartum bleeding, some hospitals allow pregnant women to take vitamin K orally every day until delivery to prevent them from such even small-risk bleeding, while at the same time The fetus is also protected by vitamin K.

The main goal of treating obstetric cholestasis in pregnant women is to eliminate the possibility of fetal death in the mother's womb. When the fetus's lungs are mature and able to adapt to life outside the womb, it should be delivered as soon as possible. Doctors now believe that pregnant women with obstetric cholestasis are best given birth within 35 to 38 weeks of pregnancy. If a pregnant woman induces labor within this time frame, the baby has a high chance of survival, but if she waits until 40 weeks of pregnancy to give birth, the baby has an increased chance of intrauterine fetal death.