A retired female teacher received regular bisphosphonate treatment for osteoporosis. Unexpectedly, after 13 months of medication, the mandible was severely inflamed, and a large area was necrotic and suppurated. The US Food and Drug Administration pointed out that although the risk of jawbone necrosis is not common, once it happens, it may cause very serious trouble, reminding users to pay attention to oral hygiene and form a good habit of regular oral examination. Jeong-cheol Lee, Ph.D., Department of Oral and Maxillofacial Surgery, National Taiwan University Hospital, said that bisphosphonates are often used to treat osteoporosis, cancer bone metastasis and bone resorption of multiple myeloma because they can inhibit bone resorption. The most commonly used bisphosphonate drugs in clinic are oral fosamax once a week and intravenous injection of Zhuoguta once a month. However, patients who take these drugs may have serious side effects such as osteomyelitis or osteonecrosis of jaws if they undergo tooth extraction, tooth implantation or alveolar bone surgery. Recent studies have also found that the longer the bisphosphonate test time, the more times and the denser the frequency, the higher the risk of osteomyelitis, osteonecrosis of jaw and atypical femoral fracture. Dr. Jeong-cheol Lee further explained that the symptoms of early jaw necrosis were similar to periodontal disease, including oral pain, swelling and suppuration of gums, gum ulcers, loose teeth and alveolar bone exposure. Only "prevention" is the best way to treat bisphosphonate-related jaw necrosis. Therefore, Dr. Jeong-cheol Lee reminded users to pay special attention to oral hygiene and have an oral examination with a dentist every six months. If dental operations such as tooth extraction and tooth implantation are needed, the doctor should be informed that bisphosphonates are being used. In case of discomfort (such as swollen gums, loose teeth, jaw pain, etc.). ), you should return to the original prescriber as soon as possible. The US Food and Drug Administration also called for bone relaxants not to be health products for bone preservation. Don't listen to the introduction of relatives and friends, take medicine without a doctor's prescription, or you won't get the subsidy in case of unfortunate drug damage. In addition, the department also reminded medical staff and patients that once any adverse reactions suspected to be caused by drug use are found, they should immediately notify the National Adverse Drug Reaction Notification Center. Subscribe to the health Aloha audio-visual channel, read health knowledge more easily, and pay attention to your health every day! Line @ ID: @:/supply/article/14457/Female teachers take osteoporosis drugs. Jaw necrosis Keywords: National Taiwan University Hospital, Oral and Maxillofacial Surgery, Jeong-cheol Lee, bisphosphonates, osteoporosis, cancer and bone metastasis.