The clinical manifestations of intraductal papilloma of breast are abnormal nipple discharge and breast mass. Unexplained abnormal nipple discharge is often the first symptom in clinic. Most of them are bloody discharge, and a few are serous discharge or both appear alternately. About 50% of pathological nipple discharge is caused by intraductal papilloma of breast. (Human Papillomavirus) Human Papillomavirus (HPV) is a kind of papillomavirus A belonging to the family Papilloviridae. It is a spherical DNA virus that can cause squamous epithelial hyperplasia of human skin and mucosa. Manifested as common warts, genital warts (condyloma acuminatum) and other symptoms.