The connotation of transsexual surgery is different between transsexual women (MtF) and transsexual men (FtM). For transgender women, this kind of surgery usually includes vaginoplasty and breast augmentation, while for transgender men, this kind of surgery includes various procedures, such as mastectomy, male breast plastic surgery and penile plastic surgery. In addition, transsexual men will undergo hysterectomy and bilateral ovarian salpingectomy.

However, thoracic (upper) surgery is often the only surgery for many female-to-male transsexuals, mainly the sexual replacement surgery in genitals is not ideal, and its appearance and function need to be improved. Other transgender women will undergo facial feminization surgery and breast augmentation, which is also an important part of the gender reset process.

People who seek sex-change surgery are usually called transsexuals, in which English trans means crossing, crossing and changing, while sexual refers to sexual characteristics, not sexual orientation. Recently, people who seek sex replacement surgery are more commonly called transgender; To some people, "transsexuality" is milder than "transsexuality".