Bonida was approved by the State Medical Supplies Administration on 20 12 and 10 for injection filling between deep dermis and superficial dermis. Bonida not only plays the role of filling, but also keeps the skin elastic.

Ryerson took a different approach. Ryerson's liquid bone carving is based on silicate, which provides a suitable environment for new tissues and accelerates tissue repair and regeneration. It lasts longer than hyaluronic acid, does not repel, and has no repair period, so Ryerson is better.