Personal Honor 20 18 On August 3, according to the relevant provisions of the Measures for the Management of National Science Fund for Distinguished Young Scholars, the National Natural Science Foundation of China announced the list of applicants for the supported projects of National Science Fund for Distinguished Young Scholars in 20 18, and Huang Zhiwei was among them.
20 18, 1 1, won Tan Life Science Innovation Award.
Research direction The research in our laboratory is divided into two parts:
1. Relationship between structure and function of important biological macromolecules (soluble/membrane proteins and nucleic acids) in immunology and neurobiology. Cell surface receptors sense and respond to extracellular signals like antennas. We studied the relationship between the structure and function of receptor/ligand complex on membrane, which is involved in important cell signal transduction. Our research will be used to answer the following questions: How are ligands recognized by corresponding receptors (such as GPCRs) on the cell surface? How are their mutual recognition specificity/selectivity achieved? What changes have taken place in the conformation of the receptor after binding the ligand? How does the change of receptor conformation activate or inhibit intracellular signaling pathways? How do regulatory proteins regulate the function of receptors? In addition, we also studied the relationship between the structure and function of protein (complex) in important cells involved in immunity and nerve signal transduction.
2. Study on new genes activated by natural immune system and their signal pathways: signal molecules regulating the differentiation and activity of immune cells (such as macrophages) and their signal transduction mechanisms, and inflammatory body activation.
In addition to the basic research of structural biology and signal pathway, we also analyzed the structure of soluble/membrane protein (complex) which plays a key role in immune and neurodegenerative diseases, and used these structural information to reasonably design small molecular drugs to treat the above diseases. The research results were published in Cell Host &; Microbes (IF= 13.728). Molecular biology (if = 13.685) and other journals.
Molecular mechanism of interaction between virus and host immune system.
Main contribution 1. Wei Guozou, Jassim, Nicholas Brady, Dorothy Hu, Li Bedlap, Kirsten siegrist, Laurie H Grimcher, Dallas Jones (20 1 1). E3 ubiquitin ligase Wwp2 regulates craniofacial development through single ubiquitination in geese. Natural cell biology. 13, 59-65.
2. Chen D, Lei L, Fu Roriz R, Wu Z, Chai J, Zhong G. Processing and self-activation of secretory protease CPAF in chlamydia infected cells. Pathogenic mechanism of microorganisms. 1( 10), 1- 10.
3. Hechai (20 10). Drawing selection mechanism diagram through bacterial GEFs. Toxicity. 1(2), 1-4.
4. Sarah e Sutton *, Adam j warrenfang, Robert c Orchard, Wu Xiaojing 1, feng, chai and Neil m Aalto (2009). Structural insight of bacterial GEF mimetic family on host GTP enzyme subtype selection. Natural structure and architecture. Molecular biology. 16(8), 853-860.(* co-first author, this publication was selected as the research "highlight" by Nature China).
5. Feng,,, Wu Xiaojing, Xiao Xingguo,, Niuhuang, Gu Lichuan, Zhong Guangming, Chai (2008). Structural basis of activation and inhibition of secretory chlamydia protease CPAF. Cell host & Microorganisms. 4(6), 529-542. (This publication was selected as the research "highlight" by Nature China)
6. Mike Olson, Huang Zhiwei, Neil Aalto, Jack Dixon, Ji Jie Chai and Samuel Miller (2008). The structure and function of Salmonella SifA indicate that its interaction with SKIP, SseJ and RhoA family GTP enzymes induces endosomal tubulation. Cell host & Microorganisms. 4(5), 434-446.