The hospital, formerly known as Huaihe Hospital in Henan Province, was founded in 1955. 1965 was renamed Kaifeng people's hospital; 1984 was renamed Huaihe hospital affiliated to Kaifeng medical college due to the merger of cities; 1995 was renamed Huaihe hospital of Kaifeng college; In 2000, due to the merger of Henan University, Kaifeng Hospital and Kaifeng Normal College, it was renamed Huaihe Hospital of Henan University.