His eyes look like his father's.

Explanation:

1. Comparison is based on the comparison of similar things, and it is impossible to compare eyes with people and exclude AB;

2. His mother's eyes = his mother's eyes

The possessive form of nouns has both adjectives and nouns.

His mother's is very interesting. Does he have many mothers? That is the possessive form of the noun plural mother.

3. So exclude C, and the correct answer is D.