Hyaluronic acid is a substance in the basal layer of human skin. When it is filled and injected into the skin, it will be continuously absorbed and decomposed by the human body without any toxic or side effects. It is the safest cosmetic filler at present. Medically, it is agreed that the shorter the residence time of substances filled in the human body, the safer it is for human health, and the trend of human muscles and skin will change to some extent with the increase of age. If the time is too long, it will easily lead to disharmony between the filler and the later muscle structure, which will affect the appearance. Generally, the retention time of hyaluronic acid is 6- 12 months. Of course, this is related to everyone's metabolism and nursing situation, and some long-acting hyaluronic acid can last longer.