And phosphate groups. The route of excretion is mainly through single channel or through kidney and liver and gallbladder, such as benazepril.
And fosinopril. Drugs discharged through dual channels can be used for the elderly with renal insufficiency. Half-life (T 1/2)
Some are long, some are short, captopril T 1/22 ~ 3 hours, enalapril T 1/21/hour, benazepril t1/2.
10 ~ 1 1 hour. In order to reduce blood pressure fluctuation and increase patient compliance, T 1/2 should be chosen once a day.
The second management. In addition, it is necessary to consider whether the metabolites still have pharmacological activities, such as enalapril and cilazapril.
La, fosinoprila, make the drug effect last long and the peak concentration is low.
Another important parameter for reasonable selection is Tmax of drugs, because it is closely related to the time course of antihypertensive effect.
The early antihypertensive effect of ACEI mainly comes from blocking RAS in blood circulation, and its continuous antihypertensive effect is in the blocking group.
RAS in weaving. Generally speaking, long-acting drugs with a duration of more than 24 hours are called long-acting drugs, while others have medium or short-acting effects.
Effective drugs.
Almost all ACEI can cause cough, which is characterized by irritating persistent dry cough, and it is easy to recover after stopping taking drugs.
The incidence of dry cough caused by different ACEI is different, and the incidence of cough is affected by different clinical trial data.
There are also great differences in the report. The incidence of ACEI dry cough is closely related to dosage, course of treatment and primary disease.