In the summer of 2003, Anning Hospital was officially renamed as the Second People's Hospital of Guizhou Province, and the brand of Guizhou Mental Health Center was added.
In 2004, the Second Affiliated Hospital of Zunyi Medical College was merged into the Second People's Hospital of Guizhou Province, bringing a large number of comprehensive medical talents.
In June 2009, the comprehensive outpatient building of the Second Provincial Hospital with a total construction area of 35,600 square meters was officially started.