Microcrystalline sphere fillers are made of biodegradable materials such as polylactic acid or polyvinyl alcohol. Microcrystalline sphere filler is a medical filling material, mainly composed of tiny spherical particles, usually made of biodegradable materials such as polylactic acid or polyvinyl alcohol. It is widely used in plastic surgery and cosmetology to fill facial wrinkles, enhance volume in areas such as lips and cheeks, and improve skin texture and contours. Microcrystalline spheres are a spherical structure formed by the aggregation of tiny crystals. So microcrystalline sphere fillers are made of biodegradable materials such as polylactic acid or polyvinyl alcohol.