First of all, look at the area. If it is not big, rinse it with cold water first, dry it and then apply it with MEBO. Note that if there are blisters, remove them before taking the medicine. According to the instructions, it is best to use it every 4 hours. Every time you apply it, remove the original medicine before applying it. At the same time, you can take antibiotics orally to prevent infection. If the area is too large, go to the hospital for treatment.