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Why cute rabbits should contribute to medicine

Rabbits are one of the earliest experimental animals domesticated by humans for experimental research. They are widely used in biomedical acute experiments, endocrine experiments, substance metabolism experiments, pharmacology experiments, etc.

(1) Fever research and heat source test

Rabbits are sensitive to heat source substances and are routinely used as heat sources for pharmaceutical and drug testing departments to inspect products.

(2) Applications in microbiology, immunology and biological products

1. Rabbits are very sensitive to a variety of microorganisms, so smallpox, encephalitis, and rabies can be established , chronic staphylococcal osteomyelitis and animal models of schistosomiasis, toxoplasma and other diseases, used to study corresponding diseases in humans.

2. After antigen stimulates the body, rabbits have a strong humoral immune response and are widely used to prepare immune serum with high potency and specificity.

(3) Research on cardiovascular disease and pulmonary heart disease

The cervical neurovascular and thoracic cavity of rabbits are very suitable for acute cardiovascular experiments; they can replicate the effects of cardiovascular disease and pulmonary heart disease Animal model: Hyperlipidemia, aortic atherosclerotic plaque, coronary atherosclerosis and other lesions formed in rabbits are very similar to human lesions.

(4) Research on Reproductive Physiology and Embryology

Rabbits are stimulated ovulators. Male rabbits can induce ovulation by mating or by injecting 80 to 100 units of chorionic gonadotropin. , can accurately determine the time of ovulation and easily obtain embryo materials at the same time. It can also be used in contraceptive research to observe the impact of drugs on ovulation.

(5) Applications in other aspects

1. Rabbits have large eyeballs, which are convenient for surgical operations and observation, and are the most commonly used animals in ophthalmic research. The distribution of blood vessels in the neck and jaw is similar to that of humans. As a sensitive animal to observe the Arthus reaction of the dental pulp, it can be used for research on oral mucosal disease, periodontal disease, plastic material toxicity test and cleft lip, cleft palate and other deformities.

2. Rabbits are often used to study the effects of cosmetics on the skin; to test skin reactions such as toxins and toxoids in various human and animal biological products.

3. Rabbits are commonly used experimental animals to replicate human disease models such as diabetes models and tachyarrhythmia models.